Description

5-Bromo-2,3-Difluoro-Benzaldehyde is a high-purity fluorinated and brominated aromatic aldehyde building block. This compound is valued for its unique reactivity profile, where the aldehyde group serves as a versatile handle for further chemical transformations, while the halogen substituents (bromine and fluorine) allow for selective cross-coupling and functionalization reactions. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated and brominated aromatic cores for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the halogen atoms contribute to binding affinity and environmental persistence.
• Material Science Precursor: Serves as a monomer or precursor in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom is an excellent site for palladium-catalyzed reactions (e.g., Suzuki, Heck, Sonogashira), enabling the construction of complex biaryl structures.
• Organic Synthesis & Research: A versatile reagent in academic and industrial R&D labs for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	5-Bromo-2,3-Difluoro-Benzaldehyde
CAS No.	633327-22-7
Molecular Formula	C7H3BrF2O
Molecular Weight	221.00 g/mol
Synonyms	2,3-Difluoro-5-bromobenzaldehyde; 5-Bromo-2,3-difluorobenzaldehyde; Benzaldehyde, 5-bromo-2,3-difluoro-; 633327-22-7; 5-Bromo-2,3-difluoro-benzaldehyde; 2,3-Difluoro-5-bromo-benzaldehyde
EINECS	Contact for details

Quality Control

Our 5-Bromo-2,3-Difluoro-Benzaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We can support development projects requiring compliance with ICH guidelines and other relevant regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is easily oxidized and should be handled under an inert atmosphere for long-term storage or after opening. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.