Description

1-C-[2,4-Bis(1,1-Dimethylethoxy)-5-Pyrimidinyl]-5-o-(1-Methoxy-1-Methylethyl)-2,3-o-(1-Methylethylidene)-α-D-Ribofuranose is a sophisticated, high-purity nucleoside derivative and a critical advanced intermediate in modern pharmaceutical synthesis. This compound matters because it provides a protected and functionalized ribose scaffold essential for constructing complex antiviral and anticancer nucleotide analogs. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of next-generation therapeutics, particularly for targeting viral polymerases and specific cellular enzymes.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel nucleoside-based antiviral and anticancer prodrugs.
• Antiviral Drug Research: Used in the development of therapeutics targeting viruses such as Hepatitis C (HCV), SARS-CoV-2, and other RNA viruses.
• Oncology Research: Serves as a precursor for nucleotide analogs designed to inhibit cancer cell proliferation.
• ProTide Technology: A vital intermediate in the synthesis of ProTide prodrugs, which enhance the cellular delivery and efficacy of nucleotide monophosphates.
• Biochemical Research: Employed in enzymatic studies and as a substrate analog to investigate polymerase mechanisms.
• Process Chemistry & Scale-Up: Used in route development and optimization for the commercial manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	1-C-[2,4-Bis(1,1-Dimethylethoxy)-5-Pyrimidinyl]-5-o-(1-Methoxy-1-Methylethyl)-2,3-o-(1-Methylethylidene)-α-D-Ribofuranose
CAS No.	631920-67-7
Molecular Formula	C24H40N2O8
Molecular Weight	484.59 g/mol
Synonyms	1-[(2R,3R,4R,5R)-3,4-Bis(1-methylethylidene)-5-[(2-methoxypropan-2-yl)oxy]oxolan-2-yl]-2,4-bis(2-methylpropan-2-yloxy)pyrimidine-5-carbonitrile; 2',3'-Isopropylidene-5'-O-(1-methoxy-1-methylethyl)-2,4-di-tert-butoxy-5-cyanopyrimidine riboside; 5-Cyano-2,4-di-tert-butoxy-1-[(2R,3R,4R,5R)-3,4-isopropylidenedioxy-5-((2-methoxypropan-2-yl)oxy)tetrahydrofuran-2-yl]pyrimidine; Protected 5-Cyanouridine Derivative; Advanced Nucleoside Intermediate; 631920-67-7
EINECS	Contact for details

Quality Control

Our 1-C-[2,4-Bis(1,1-Dimethylethoxy)-5-Pyrimidinyl]-5-o-(1-Methoxy-1-Methylethyl)-2,3-o-(1-Methylethylidene)-α-D-Ribofuranose is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled, low-humidity environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.