Description

4,5-Difluoroindan-1-One is a high-purity fluorinated organic building block of significant interest in advanced chemical synthesis. This compound matters for its role as a key intermediate in the development of complex molecules, particularly within the pharmaceutical and agrochemical sectors. It is primarily needed by R&D chemists and process development scientists working on novel active ingredients, where its difluorinated indanone scaffold offers unique electronic and steric properties for structure-activity optimization.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides, leveraging the fluorine atoms for enhanced bioactivity and metabolic stability.
• Material Science Precursor: Serves as a monomer or precursor for specialty polymers and liquid crystals, where the fluorinated aromatic system can modify material properties.
• Organic Electronic Materials: Investigated for use in the synthesis of organic semiconductors and charge-transport materials for OLEDs and photovoltaic applications.
• Chemical Research & Development: Employed in academic and industrial labs for methodological studies in fluorination chemistry and cross-coupling reactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and development of scalable synthetic routes for clients.

Basic Information

Product Name	4,5-Difluoroindan-1-One
CAS No.	628732-11-6
Molecular Formula	C9H6F2O
Molecular Weight	168.14 g/mol
Synonyms	1-Indanone, 4,5-difluoro-; 4,5-Difluoro-1-indanone; 4,5-Difluoroindanone; 4,5-Difluoro-2,3-dihydro-1H-inden-1-one; 628732-11-6; 4,5-Difluoro-1-indan-1-one; 4,5-Difluoro-2,3-dihydroinden-1-one
EINECS	Contact for details

Quality Control

Our 4,5-Difluoroindan-1-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and contamination. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.