Description

n-Fmoc Dmnb-L-Serine is a specialized, orthogonally protected amino acid derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound matters for its dual-protection strategy, where the Fmoc group safeguards the α-amino function and the Dmnb (1-(4,5-dimethoxy-2-nitrophenyl)ethyl) group provides a photolabile protecting group for the serine side-chain hydroxyl, enabling precise, sequential deprotection under mild conditions. It is an essential building block for researchers and manufacturers in pharmaceutical development, particularly for synthesizing complex peptides, glycopeptides, and bioconjugates where selective side-chain manipulation is critical.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, enabling the construction of serine-containing peptides with orthogonal side-chain protection.
• Photocleavable Linker Chemistry: Utilized in the synthesis of peptides and biomolecules attached to solid supports via photolabile linkers for controlled release.
• Glycopeptide Synthesis: Serves as a precursor for introducing glycosylated serine residues into peptide backbones under mild deprotection conditions that are compatible with sensitive glycosidic bonds.
• Combinatorial Chemistry Libraries: Used in the generation of diverse peptide libraries for drug discovery and high-throughput screening applications.
• Bioconjugation and Probe Development: Acts as an intermediate for creating peptide-based fluorescent probes, imaging agents, and antibody-drug conjugates (ADCs) with site-specific modifications.
• Research & Development: Critical for academic and industrial R&D focused on novel peptide therapeutics, including antimicrobial peptides and hormone analogs.

Basic Information

Product Name	n-Fmoc Dmnb-L-Serine
CAS No.	628280-43-3
Molecular Formula	C₃₁H₃₂N₂O₉
Molecular Weight	576.60 g/mol
Synonyms	Fmoc-Ser(Dmnb)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-[1-(4,5-dimethoxy-2-nitrophenyl)ethyl]-L-serine; Fmoc-L-Serine(Dmnb)-OH; Fmoc-O-(1-(4,5-dimethoxy-2-nitrophenyl)ethyl)-L-serine; L-Serine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 1-(4,5-dimethoxy-2-nitrophenyl)ethyl ester; N-α-Fmoc-O-Dmnb-L-serine
EINECS	Contact for details

Quality Control

Our n-Fmoc Dmnb-L-Serine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is strictly light-sensitive (protect from all light exposure) and hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation. For long-term storage, keep desiccated at low temperature.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% L-isomer
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.