Description

Boc-2-Thiazolyl-L-Alanine is a specialized, non-proteinogenic amino acid derivative where the thiazole heterocycle is incorporated into the side chain of L-alanine, protected by a tert-butoxycarbonyl (Boc) group on the amine. This compound is a critical building block in peptide synthesis and medicinal chemistry, enabling the introduction of the unique thiazole moiety, which can impart specific electronic and hydrogen-bonding properties to target molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel bioactive peptides, enzyme inhibitors, and drug candidates, particularly for exploring structure-activity relationships.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of complex peptides containing thiazolylalanine residues.
• Medicinal Chemistry & Drug Discovery: Used in the design and synthesis of peptide-based drug candidates, enzyme inhibitors, and receptor ligands where the thiazole ring acts as a bioisostere or pharmacophore.
• Bioconjugation & Chemical Biology: Serves as a modified amino acid for introducing functional handles or fluorescent tags into proteins and peptides for probing biological interactions.
• Academic & Industrial Research: Employed in fundamental research to study peptide structure, stability, and folding, as well as in high-throughput screening libraries.

Basic Information

Product Name	Boc-2-Thiazolyl-L-Alanine
CAS No.	627910-28-5
Molecular Formula	C11H16N2O4S
Molecular Weight	272.32 g/mol
Synonyms	(2S)-2-[(tert-Butoxycarbonyl)amino]-3-(1,3-thiazol-2-yl)propanoic acid; Boc-Thz-Ala-OH; Boc-L-2-Thiazolylalanine; N-α-(tert-Butoxycarbonyl)-2-thiazolyl-L-alanine; tert-Butyloxycarbonyl-2-thiazolyl-L-alanine; N-Boc-2-thiazolyl-L-alanine; (S)-2-((tert-Butoxycarbonyl)amino)-3-(thiazol-2-yl)propanoic acid
EINECS	Contact for details

Quality Control

Our Boc-2-Thiazolyl-L-Alanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and comprehensive spectroscopic identification (NMR, IR, MS). A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.