Description

Antide Acetate is a synthetic peptide analog known for its potent antagonistic activity against gonadotropin-releasing hormone (GnRH) receptors. This compound is a critical research tool and pharmaceutical intermediate, valued for its high specificity and biological stability. It is primarily utilized by researchers and manufacturers in the fields of endocrinology, oncology, and reproductive medicine for advanced studies and therapeutic development.

Application

• Pharmaceutical Research & Development: As a key intermediate in the synthesis of novel GnRH antagonist-based therapeutics for hormone-dependent conditions.
• Endocrinology Studies: Used in preclinical and clinical research to investigate the regulation of the hypothalamic-pituitary-gonadal axis.
• Oncology Research: Employed in studies targeting hormone-sensitive cancers, such as prostate and breast cancer, due to its ability to suppress sex hormone production.
• Reproductive Medicine: Serves as a reference standard and active component in developing treatments for endometriosis, uterine fibroids, and assisted reproduction protocols.
• Biochemical Assay Development: Used as a ligand in receptor binding assays and for calibrating analytical methods (HPLC, MS) in quality control laboratories.
• Veterinary Pharmaceuticals: Potential application in the development of treatments for reproductive disorders in animals.

Basic Information

Product Name	Antide Acetate
CAS No.	625092-10-6
Molecular Formula	C81H112N20O17 • xC2H4O2
Molecular Weight	~1661.9 g/mol (free base)
Synonyms	Acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridyl)-D-alanyl-L-seryl-N6-[[[4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl]carbonyl]amino]-L-lysyl-N6-[[[4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl]carbonyl]amino]-L-lysyl-L-leucyl-N6-[[[4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl]carbonyl]amino]-L-lysyl-L-prolyl-D-alaninamide Acetate; GnRH Antagonist (Antide); [Ac-D2Nal1, D4Cpa2, D3Pal3, Lys(Nic)5, D Lys(Nic)6, Lys(iPr)8, D-Ala10]GnRH
EINECS	Contact for details

Quality Control

Our Antide Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting results for assay, related substances, residual solvents, and other critical parameters. We adhere to cGMP guidelines where applicable to support our clients' regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 99.0%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (IC)	3.0 - 8.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.