Description

(2E)-n-Benzyl-2-Cyano-3-[2-(4-Fluorophenoxy)-9-Methyl-4-Oxo-4H-Pyrido[1,2-A]Pyrimidin-3-Yl]Prop-2-Enamide is a sophisticated heterocyclic organic compound featuring a pyrido[1,2-a]pyrimidinone core, designed for advanced research and development. This high-purity intermediate is critical for pharmaceutical chemists exploring novel bioactive molecules, particularly in kinase inhibition and targeted therapeutic areas. It is primarily utilized by pharmaceutical R&D laboratories and contract research organizations (CROs) engaged in the synthesis of new chemical entities.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of potential drug candidates, especially those targeting specific enzyme pathways.
• Kinase Inhibitor Research: Used in the development and optimization of novel kinase inhibitors due to its privileged pyrido[1,2-a]pyrimidinone scaffold.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to explore new pharmacophores and enhance compound libraries.
• Biochemical Assay Development: Acts as a reference standard or probe molecule in high-throughput screening and biochemical assays.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and heterocyclic chemistry.
• Preclinical Development: Supports the early-stage development of new therapeutic agents before clinical trials.

Basic Information

Product Name	(2E)-n-Benzyl-2-Cyano-3-[2-(4-Fluorophenoxy)-9-Methyl-4-Oxo-4H-Pyrido[1,2-A]Pyrimidin-3-Yl]Prop-2-Enamide
CAS No.	620113-66-8
Molecular Formula	C27H19FN4O3
Molecular Weight	466.47 g/mol
Synonyms	(2E)-N-Benzyl-2-cyano-3-[2-(4-fluorophenoxy)-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]prop-2-enamide; 2-Propenamide, N-benzyl-2-cyano-3-[2-(4-fluorophenoxy)-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]-, (2E)-; (E)-N-Benzyl-2-cyano-3-(2-(4-fluorophenoxy)-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylamide; CAS 620113-66-8; 3-(2-Cyano-2-(benzylcarbamoyl)vinyl)-2-(4-fluorophenoxy)-9-methylpyrido[1,2-a]pyrimidin-4-one; (2E)-N-Benzyl-3-[2-(4-fluorophenoxy)-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]-2-cyanoacrylamide
EINECS	Contact for details

Quality Control

Our (2E)-n-Benzyl-2-Cyano-3-[2-(4-Fluorophenoxy)-9-Methyl-4-Oxo-4H-Pyrido[1,2-A]Pyrimidin-3-Yl]Prop-2-Enamide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.