Description

(2E)-2-Cyano-n-Cyclohexyl-3-[2-(4-Ethylphenoxy)-4-Oxo-4H-Pyrido[1,2-A]Pyrimidin-3-Yl]Prop-2-Enamide is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs) targeting specific therapeutic pathways. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities, particularly in the areas of oncology and anti-inflammatory drug discovery.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of novel drug candidates, particularly for kinase inhibitors.
• Organic Synthesis Research: Used in academic and industrial R&D labs for constructing complex pyrido[1,2-a]pyrimidinone scaffolds.
• Biochemical Tool Compound: Serves as a reference standard or a probe molecule in biological screening assays and mechanism-of-action studies.
• Preclinical Development: Employed in the scale-up synthesis for producing batches required for toxicology and pharmacokinetic studies.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP guidelines.

Basic Information

Product Name	(2E)-2-Cyano-n-Cyclohexyl-3-[2-(4-Ethylphenoxy)-4-Oxo-4H-Pyrido[1,2-A]Pyrimidin-3-Yl]Prop-2-Enamide
CAS No.	620106-82-3
Molecular Formula	C27H26N4O3
Molecular Weight	454.53 g/mol
Synonyms	(2E)-2-Cyano-3-[2-(4-ethylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]-N-cyclohexylprop-2-enamide; 2-Cyano-N-cyclohexyl-3-[2-(4-ethylphenoxy)-4-oxopyrido[1,2-a]pyrimidin-3-yl]prop-2-enamide; (E)-2-Cyano-3-(2-(4-ethylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)-N-cyclohexylacrylamide; 620106-82-3; Prop-2-enamide, 2-cyano-N-cyclohexyl-3-[2-(4-ethylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]-, (2E)-
EINECS	Contact for details

Quality Control

Our (2E)-2-Cyano-n-Cyclohexyl-3-[2-(4-Ethylphenoxy)-4-Oxo-4H-Pyrido[1,2-A]Pyrimidin-3-Yl]Prop-2-Enamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing HPLC purity, NMR confirmation, and other critical parameters are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. Long-term storage under inert atmosphere (e.g., nitrogen or argon) is recommended for optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.