Description

Vorapaxar is a potent and selective antagonist of protease-activated receptor-1 (PAR-1), which plays a critical role in thrombin-mediated platelet activation. This targeted mechanism makes it a valuable compound for advanced research in cardiovascular pharmacology and thrombosis. It is primarily utilized by pharmaceutical R&D teams and academic researchers focused on developing novel antiplatelet therapies and studying hemostatic pathways. The compound is supplied to meet the stringent requirements of preclinical and analytical applications.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for quality control and analytical method development in drug manufacturing.
• Cardiovascular Research: A key tool for investigating PAR-1 receptor signaling, platelet aggregation inhibition, and mechanisms of arterial thrombosis.
• Preclinical Drug Development: Employed in *in vitro* and *in vivo* studies to evaluate the efficacy and safety profiles of next-generation antithrombotic agents.
• Biochemical Assays: Serves as a specific inhibitor in enzymatic and cellular assays to elucidate thrombin's role in various physiological and pathological processes.
• Academic Research: Utilized in university and institutional labs for fundamental studies on hemostasis, vascular biology, and inflammation.

Basic Information

Product Name	Vorapaxar
CAS No.	618385-01-6
Molecular Formula	C29H33FN2O4
Molecular Weight	492.59 g/mol
Synonyms	SCH 530348; Zontivity (brand name); (1R,3aR,4aR,6R,8aR,9S,9aS)-9-({(E)-2-[5-(3-Fluorophenyl)-2-pyridinyl]ethenyl}hexahydro-1-methyl-3-oxo-1H,3H-oxazolo[3,4-a]pyrazine-6(5H)-carboxylate; 1H,3H-Oxazolo[3,4-a]pyrazine-6(5H)-carboxylic acid, 9-[(1E)-2-[5-(3-fluorophenyl)-2-pyridinyl]ethenyl]hexahydro-1-methyl-3-oxo-, (1R,3aR,4aR,6R,8aR,9S,9aS)-
EINECS	Contact for details

Quality Control

Our Vorapaxar is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR, MS), purity determination by HPLC, and control of related substances. Certificates of Analysis (COA) are provided, detailing all test results against established specifications to ensure compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C, in a dry environment. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥98.0%
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.