Description

4-(tert-Butoxy)-2-Chloropyrimidine is a high-purity, versatile pyrimidine derivative used as a key synthetic intermediate in advanced organic chemistry. Its value lies in the strategic reactivity of the chloropyrimidine core and the tert-butoxy protecting group, enabling precise molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and plant growth regulators.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of organic electronic materials, such as components for OLEDs or conductive polymers.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.
• Academic & R&D Laboratories: Used in university and industrial research settings for methodological development and exploring new chemical entities.

Basic Information

Product Name	4-(tert-Butoxy)-2-Chloropyrimidine
CAS No.	614729-28-1
Molecular Formula	C8H11ClN2O
Molecular Weight	186.64 g/mol
Synonyms	2-Chloro-4-(tert-butoxy)pyrimidine; 4-tert-Butoxy-2-chloropyrimidine; 2-Chloro-4-(1,1-dimethylethoxy)pyrimidine; 4-(1,1-Dimethylethoxy)-2-chloropyrimidine; 4-(tert-Butyloxy)-2-chloropyrimidine; Pyrimidine, 2-chloro-4-(1,1-dimethylethoxy)-; 2-Chloro-4-tert-butoxypyrimidine
EINECS	Contact for details

Quality Control

Our 4-(tert-Butoxy)-2-Chloropyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider maintaining the material under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.