Description

n-(Fmoc-8-Amino-3,6-Dioxa-Octyl)-Succinamic Acid is a specialized, high-purity building block designed for solid-phase peptide synthesis (SPPS) and bioconjugation. This compound is critical for researchers and manufacturers who require precise, reliable, and high-yielding incorporation of a hydrophilic polyethylene glycol (PEG)-like spacer arm into peptide sequences. It is primarily utilized by pharmaceutical R&D teams, CROs, and fine chemical suppliers focused on developing therapeutic peptides, peptide-drug conjugates, and advanced biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid derivative for the automated synthesis of peptides containing a hydrophilic 8-amino-3,6-dioxaoctanoic acid (PEG2) linker.
• Peptide-Drug Conjugates (PDCs): Enables the site-specific attachment of cytotoxic drugs or imaging agents to peptide targeting vectors via a stable amide bond and a solubilizing spacer.
• Bioconjugation & Labeling: Used to introduce functional handles (via the free carboxylic acid) for coupling fluorophores, biotin, or other probes to biomolecules, improving water solubility.
• Linker Chemistry in PROTACs: Serves as a component in the synthesis of Proteolysis Targeting Chimeras (PROTACs) and other bifunctional molecules, where a flexible, hydrophilic linker is advantageous.
• Synthesis of PEGylated Peptides: Facilitates the incorporation of short, defined PEG segments directly into the peptide backbone to enhance pharmacokinetic properties.
• Research & Development: A key reagent in academic and industrial labs for exploring novel peptide architectures and linker technologies.

Basic Information

Product Name	n-(Fmoc-8-Amino-3,6-Dioxa-Octyl)-Succinamic Acid
CAS No.	613245-91-3
Molecular Formula	C27H32N2O8
Molecular Weight	512.56 g/mol
Synonyms	Fmoc-8-Amino-3,6-dioxaoctanoic Acid; Fmoc-Adoo-OH; Fmoc-N-amido-PEG2-acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-8-amino-3,6-dioxaoctanoic Acid; 2-[[2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]acetyl]acetic Acid; Fmoc-NH-PEG2-CH2CH2COOH; 8-[(9-Fluorenylmethyloxycarbonyl)amino]-3,6-dioxaoctanoic Acid; Fmoc-8-amino-3,6-dioxaoctanoic Acid
EINECS	Contact for details

Quality Control

Our n-(Fmoc-8-Amino-3,6-Dioxa-Octyl)-Succinamic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and KF titration for moisture content, to ensure it meets the exacting standards required for peptide synthesis. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability, consistency, and compliance with research and cGMP-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This material is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0% (Area %)
Assay	≥ 97.0% (by titration)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.