Description

5-Nitro-2-Trifluoromethyl-Phenol is a versatile fluorinated aromatic building block of significant interest in advanced chemical synthesis. Its molecular structure, featuring both a nitro and a trifluoromethyl group on a phenolic core, makes it a critical intermediate for creating complex molecules with tailored properties. This compound is essential for R&D and production in the pharmaceutical and agrochemical industries, where it is used to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in areas requiring fluorinated compounds for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a precursor in the manufacture of advanced herbicides, fungicides, and pesticides, where the trifluoromethyl group often contributes to efficacy and environmental profile.
• Material Science Research: Used in the synthesis of specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing substituents.
• Dye and Pigment Intermediate: Acts as a building block for synthesizing complex dyes and pigments, leveraging the nitro group's chromophoric properties.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for constructing biaryl systems.

Basic Information

Product Name	5-Nitro-2-Trifluoromethyl-Phenol
CAS No.	612498-85-8
Molecular Formula	C7H4F3NO3
Molecular Weight	207.11 g/mol
Synonyms	2-Hydroxy-5-nitrobenzotrifluoride; 2-Trifluoromethyl-5-nitrophenol; 5-Nitro-2-(trifluoromethyl)phenol; 5-Nitro-α,α,α-trifluoro-o-cresol; Phenol, 5-nitro-2-(trifluoromethyl)-; 2-(Trifluoromethyl)-5-nitrophenol; 5-Nitro-2-trifluoromethylphenol
EINECS	Contact for details

Quality Control

Our 5-Nitro-2-Trifluoromethyl-Phenol is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure high purity and consistency. Standard quality parameters include assay (by HPLC), identification (IR), and control of key impurities. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing all test results against our stringent specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in secondary opaque packaging or amber glass.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.