Description

H-L-Tyr(Propargyl)-Oh is a non-natural, propargyl-modified tyrosine derivative used as a key building block in advanced organic synthesis. This compound is essential for researchers and manufacturers developing novel peptide-based therapeutics and bioconjugation platforms. It is particularly valuable for pharmaceutical R&D, chemical biology, and materials science applications where site-specific functionalization is required. The propargyl group provides a versatile handle for click chemistry reactions, enabling efficient and selective modifications.

Application

• Peptide Synthesis: As a modified amino acid for the solid-phase or solution-phase synthesis of novel peptide analogs with enhanced properties.
• Bioconjugation & Click Chemistry: Serving as a critical reagent for the site-specific labeling of proteins, antibodies, and other biomolecules via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Pharmaceutical Research: Used in the discovery and development of new drug candidates, including targeted therapies and antibody-drug conjugates (ADCs).
• Chemical Probe Development: Enables the creation of activity-based probes for studying enzyme function and protein-protein interactions in chemical biology.
• Materials Science: Incorporation into polymers or surfaces to create functional materials with tailored bio-interfacial properties.
• Academic Research: A fundamental tool for investigating post-translational modifications and designing synthetic biological systems.

Basic Information

Product Name	H-L-Tyr(Propargyl)-Oh
CAS No.	610794-20-2
Molecular Formula	C₁₂H₁₃NO₃
Molecular Weight	219.24 g/mol
Synonyms	L-Tyrosine, O-propargyl-; O-Propargyl-L-tyrosine; (2S)-2-Amino-3-[4-(prop-2-yn-1-yloxy)phenyl]propanoic acid; H-Tyr(Propag)-OH; Fmoc-Tyr(Propag)-OH (precursor); N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(2-propynyl)-L-tyrosine; Propargyloxy-L-phenylalanine derivative; Modified Tyrosine Amino Acid
EINECS	Contact for details

Quality Control

Our H-L-Tyr(Propargyl)-Oh is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While produced to meet general reagent-grade standards, specifications can be tailored to support cGMP development phases upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 2.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.