Description

4-[(3-Ethynyl-Phenyl)Amino]-6-(Tetrahydropyran-4-Yloxy)-7-Methoxy-Quinazoline is a high-purity, advanced pharmaceutical intermediate designed for research and development in targeted therapies. This compound is valued for its role as a key building block in the synthesis of novel kinase inhibitors and other biologically active molecules. It is primarily utilized by pharmaceutical R&D departments, biotechnology firms, and academic research institutions focused on oncology and signal transduction pathways.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of targeted therapeutic agents, particularly kinase inhibitors.
• Oncology Research: Used in the development and study of novel anti-cancer compounds that target specific cellular pathways.
• Biochemical Research: Serves as a reference standard or a tool compound for studying enzyme inhibition and cellular signaling mechanisms.
• Preclinical Development: Employed in the scale-up and optimization of synthetic routes for new chemical entities (NCEs).
• Contract Manufacturing (CMO): Supplied to organizations specializing in the custom synthesis of complex molecules for clinical trials.
• Academic Research: Utilized in university and institutional labs for medicinal chemistry projects and drug discovery programs.

Basic Information

Product Name	4-[(3-Ethynyl-Phenyl)Amino]-6-(Tetrahydropyran-4-Yloxy)-7-Methoxy-Quinazoline
CAS No.	610303-43-0
Molecular Formula	C22H21N3O3
Molecular Weight	375.42 g/mol
Synonyms	4-[(3-Ethynylphenyl)amino]-6-[(oxan-4-yl)oxy]-7-methoxyquinazoline; 6-(Tetrahydropyran-4-yloxy)-7-methoxy-4-[(3-ethynylphenyl)amino]quinazoline; 4-(3-Ethynyl-anilino)-6-(tetrahydropyran-4-yloxy)-7-methoxy-quinazoline; BMS-690514 (related to parent compound); Quinazoline derivative, 4-[(3-ethynylphenyl)amino]-6-(tetrahydro-2H-pyran-4-yloxy)-7-methoxy-; EGFR/VEGFR Inhibitor Intermediate
EINECS	Contact for details

Quality Control

Our 4-[(3-Ethynyl-Phenyl)Amino]-6-(Tetrahydropyran-4-Yloxy)-7-Methoxy-Quinazoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.