Description

L-Proline, 1-(2-Propenyl)- (9Ci) is a specialized, non-proteinogenic proline derivative featuring an allyl substitution on the nitrogen atom. This structural modification makes it a valuable chiral building block and intermediate in advanced organic synthesis, particularly for introducing proline-like motifs with additional functionalization potential. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and asymmetric catalysts. The compound, identified by CAS number 610299-77-9, is supplied to meet the stringent purity requirements of modern chemical research and process development.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new drug candidates, especially those targeting neurological and metabolic disorders.
• Peptidomimetics & Constrained Peptides: Used to synthesize modified peptide sequences where the allyl-proline moiety introduces conformational constraints or serves as a handle for further chemical modification (e.g., via click chemistry).
• Asymmetric Organocatalysis: Acts as a precursor for developing novel proline-based organocatalysts used in enantioselective synthesis, such as aldol or Mannich reactions.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes or labeled compounds for studying enzyme function and protein-protein interactions.
• Agrochemical Research: Utilized as an intermediate in the discovery of new herbicides, fungicides, or plant growth regulators with chiral centers.
• Academic & Industrial R&D: A fundamental reagent for methodological development in organic chemistry and material science research.

Basic Information

Product Name	L-Proline, 1-(2-Propenyl)- (9Ci)
CAS No.	610299-77-9
Molecular Formula	C8H13NO2
Molecular Weight	155.19 g/mol
Synonyms	1-Allyl-L-proline; (S)-1-Allylpyrrolidine-2-carboxylic acid; N-Allyl-L-proline; L-1-(2-Propenyl)proline; Allyl-L-proline; N-Allylproline; 1-(Prop-2-en-1-yl)-L-proline; (2S)-1-(Prop-2-en-1-yl)pyrrolidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our L-Proline, 1-(2-Propenyl)- (9Ci) is manufactured under a quality management system and undergoes rigorous analytical testing to ensure batch-to-batch consistency and high purity. Standard quality parameters include chiral purity (enantiomeric excess), chemical purity by HPLC, and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment. We can support development projects requiring compliance with cGMP or other regulatory standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.