Description

4-Chloro-2-(2-Fluoro-Phenyl)-Quinazoline is a high-purity, advanced pharmaceutical intermediate with a defined heterocyclic structure. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of targeted therapeutic agents. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel small-molecule drugs, particularly within oncology and CNS research.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential kinase inhibitors and other biologically active quinazoline derivatives.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs for new drug candidates.
• Chemical Reference Standard: Employed as an analytical standard for quality control and method development in API manufacturing.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions and further functionalization to create complex molecular libraries for screening.

Basic Information

Product Name	4-Chloro-2-(2-Fluoro-Phenyl)-Quinazoline
CAS No.	610276-37-4
Molecular Formula	C14H8ClFN2
Molecular Weight	258.68 g/mol
Synonyms	4-Chloro-2-(2-fluorophenyl)quinazoline; 2-(2-Fluorophenyl)-4-chloroquinazoline; Quinazoline, 4-chloro-2-(2-fluorophenyl)-; 4-Chloro-2-(o-fluorophenyl)quinazoline; 610276-37-4; 4-Chloro-2-(2-fluorophenyl)quinazoline; 4-Chloro-2-(2-fluoro-phenyl)-quinazoline
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-(2-Fluoro-Phenyl)-Quinazoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.