Description

1-(9H-Fluoren-9-Ylmethoxycarbonyl)-2-Methyl-Azetidine-2-Carboxylic Acid is a specialized Fmoc-protected azetidine derivative used as a key building block in advanced organic synthesis. This high-purity intermediate is critical for constructing complex molecular architectures, particularly in the development of novel pharmaceuticals and bioactive compounds. It is essential for research and production teams in pharmaceutical R&D, agrochemical development, and advanced material science who require reliable, high-quality chiral building blocks for peptide-mimetics and constrained scaffolds.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel Active Pharmaceutical Ingredients (APIs), especially those incorporating constrained azetidine rings to modulate bioavailability and potency.
• Peptidomimetic Research: Used in the design and solid-phase synthesis of peptide analogs and mimetics, where the Fmoc group allows for selective deprotection in sequential coupling strategies.
• Constrained Amino Acid Analogue: Serves as a precursor for non-natural, conformationally restricted amino acids, which are valuable tools in medicinal chemistry for probing structure-activity relationships.
• Agrochemical Synthesis: Employed in the research and development of new-generation crop protection agents and herbicides that utilize heterocyclic scaffolds.
• Chemical Biology Probes: Integral for creating labeled or tagged molecular probes used to study enzyme mechanisms and protein-protein interactions.
• Material Science: Potential use in the synthesis of specialty polymers and functionalized surfaces requiring specific chiral centers.

Basic Information

Product Name	1-(9H-Fluoren-9-Ylmethoxycarbonyl)-2-Methyl-Azetidine-2-Carboxylic Acid
CAS No.	610271-10-8
Molecular Formula	C22H21NO4
Molecular Weight	363.41 g/mol
Synonyms	Fmoc-2-methylazetidine-2-carboxylic acid; 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-methylazetidine-2-carboxylic acid; Fmoc-MeAze(2)-OH; N-α-Fmoc-2-methylazetidine-2-carboxylic acid; (2-Methylazetidine-2-carboxylic acid), N-Fmoc derivative; 1-(Fmoc)-2-methylazetidine-2-carboxylic acid; N-Fmoc-2-methyl-2-azetidinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 1-(9H-Fluoren-9-Ylmethoxycarbonyl)-2-Methyl-Azetidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and comprehensive identity confirmation, to ensure it meets the exacting standards required for pharmaceutical R&D and cGMP applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions or inert atmosphere to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.