Description

1,4-Benzenedicarboxaldehyde, 2,5-Difluoro- is a high-purity, fluorinated aromatic dialdehyde building block of significant interest in advanced organic synthesis. Its value lies in its dual aldehyde functionality and strategic fluorine substitution, enabling the construction of complex, functionalized molecular architectures. This compound is primarily needed by research and development chemists and process engineers in the pharmaceutical, agrochemical, and materials science industries for applications such as linker synthesis, ligand design, and the creation of novel polymers.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing heterocyclic cores and functionalized linkers.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Ligand and Catalyst Design: Serves as a versatile scaffold for creating chelating ligands and organocatalysts used in asymmetric synthesis and metal-organic frameworks (MOFs).
• Polymer and Material Science: Employed as a monomer or cross-linking agent for producing high-performance polymers, such as polyimides and polyazomethines, with tailored thermal and optical properties.
• Fluorescent Probe and Dye Synthesis: Utilized in the preparation of fluorophores and molecular sensors due to the electron-withdrawing nature of the fluorine and aldehyde groups.
• Custom Chemical Synthesis: A valuable building block for contract research organizations (CROs) and custom synthesis houses working on proprietary compounds and novel chemical entities.

Basic Information

Product Name	1,4-Benzenedicarboxaldehyde, 2,5-Difluoro-
CAS No.	608145-27-3
Molecular Formula	C8H4F2O2
Molecular Weight	170.11 g/mol
Synonyms	2,5-Difluoroterephthalaldehyde; 2,5-Difluoro-1,4-benzenedicarboxaldehyde; 2,5-Difluoroterephthalic aldehyde; Terephthalaldehyde, 2,5-difluoro-; 1,4-Bis(formyl)-2,5-difluorobenzene; 2,5-Difluoro-[1,1'-biphenyl]-4,4'-dicarboxaldehyde (incorrect but common misnomer); 2,5-Difluorobenzene-1,4-dicarbaldehyde
EINECS	Contact for details

Quality Control

Our 1,4-Benzenedicarboxaldehyde, 2,5-Difluoro- is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity, the material should be kept under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and handled in a moisture-controlled environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.