Description

3H-1,2,3-Triazolo[4,5-D]Pyrimidin-7-Amine,3-[(2-Chloro-6-Fluorophenyl)Methyl]-n-[2-(4-Morpholinyl)Ethyl]-5-(Trifluoromethyl)-(9Ci) CAS NO 606135-55-1 is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure incorporating triazolo-pyrimidine, morpholine, and trifluoromethyl moieties. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for novel active pharmaceutical ingredients (APIs). It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of targeted therapeutics, particularly in oncology and kinase inhibitor programs.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel kinase inhibitors and other targeted small-molecule drugs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic candidates.
• Chemical Biology Probes: Serves as a core scaffold for developing selective chemical probes to study biological pathways and protein functions.
• Preclinical Drug Development: Employed in the synthesis of compounds for pharmacological evaluation, toxicology studies, and formulation development.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up of complex molecules for clinical trials.
• Academic Research: Utilized in university and institutional labs for cutting-edge research in organic synthesis and drug discovery methodologies.

Basic Information

Product Name	3H-1,2,3-Triazolo[4,5-D]Pyrimidin-7-Amine,3-[(2-Chloro-6-Fluorophenyl)Methyl]-n-[2-(4-Morpholinyl)Ethyl]-5-(Trifluoromethyl)-(9Ci)
CAS No.	606135-55-1
Molecular Formula	C18H18ClF4N7O
Molecular Weight	459.83 g/mol
Synonyms	3-[(2-Chloro-6-fluorophenyl)methyl]-N-[2-(morpholin-4-yl)ethyl]-5-(trifluoromethyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-amine; 3-((2-Chloro-6-fluorobenzyl))-N-(2-morpholinoethyl)-5-(trifluoromethyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-amine; CAS 606135-55-1; 606135-55-1; 3H-[1,2,3]Triazolo[4,5-d]pyrimidin-7-amine, 3-[(2-chloro-6-fluorophenyl)methyl]-N-[2-(4-morpholinyl)ethyl]-5-(trifluoromethyl)-; 3-[(2-Chloro-6-fluorophenyl)methyl]-N-[2-(morpholin-4-yl)ethyl]-5-(trifluoromethyl)-[1,2,3]triazolo[4,5-d]pyrimidin-7-amine
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity essential for pharmaceutical research. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and LC-MS. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. We support compliance with ICH guidelines for impurities and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); ensure the container is kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.