Description

Ethyl 2-(Piperazin-1-yl)pyrimidine-5-carboxylate is a high-purity pharmaceutical intermediate featuring a pyrimidine core functionalized with a piperazine moiety and an ethyl ester group. This compound is of significant commercial importance as a versatile building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapeutics. It is primarily sought by research institutions and manufacturers in the pharmaceutical and biotechnology sectors engaged in drug discovery and development.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, especially kinase inhibitors.
• Chemical Synthesis Building Block: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Research & Development: Serves as a critical reagent in academic and industrial R&D labs for exploring new therapeutic pathways.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in the scaled-up production of final drug substances under controlled GMP environments.

Basic Information

Product Name	Ethyl 2-(Piperazin-1-yl)pyrimidine-5-carboxylate
CAS No.	603965-77-1
Molecular Formula	C11H16N4O2
Molecular Weight	236.27 g/mol
Synonyms	Ethyl 2-(1-piperazinyl)-5-pyrimidinecarboxylate; 2-(Piperazin-1-yl)pyrimidine-5-carboxylic acid ethyl ester; 5-Pyrimidinecarboxylic acid, 2-(1-piperazinyl)-, ethyl ester; Ethyl 2-piperazin-1-ylpyrimidine-5-carboxylate; 603965-77-1; UNII-8J8H6H7Q4F
EINECS	Contact for details

Quality Control

Our Ethyl 2-(Piperazin-1-yl)pyrimidine-5-carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay, identity, and impurity profiles. We adhere to relevant industry standards and can support development projects requiring material for pre-clinical and clinical stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.