Description

n-Me-Abz-Amyloid β-Protein (37-44)-Lys(Dnp)-D-Arg-D-Arg-D-Arg Amide Trifluoroacetate Salt is a specialized, high-purity synthetic peptide derivative designed for advanced biochemical and pharmacological research. This compound is critical for scientists investigating the mechanisms of amyloid-related diseases and developing targeted diagnostic or therapeutic agents. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on neuroscience, proteomics, and peptide-based drug discovery.

Application

• Biochemical Research: Used as a key reagent in studying amyloid β-protein aggregation, fibril formation, and related neurotoxicity pathways.
• Pharmaceutical Development: Serves as a reference standard or active pharmaceutical ingredient (API) intermediate in the development of novel therapeutics targeting Alzheimer's disease and other amyloidosis.
• Diagnostic Assay Development: Employed in the design and validation of immunoassays, ELISA kits, and other diagnostic tools for detecting amyloid beta peptides and their fragments.
• Proteomics & Peptide Mapping: Acts as a modified peptide standard in mass spectrometry and HPLC studies for method development and protein sequence analysis.
• Cell Biology Studies: Utilized in cellular models to examine the effects of specific amyloid beta fragments on neuronal cell viability and function.
• Inhibitor Screening: Functions as a substrate or target in high-throughput screening assays to identify potential inhibitors of amyloid beta aggregation.

Basic Information

Product Name	n-Me-Abz-Amyloid β-Protein (37-44)-Lys(Dnp)-D-Arg-D-Arg-D-Arg Amide Trifluoroacetate Salt
CAS No.	600728-90-3
Molecular Formula	C58H94N26O14 • C2HF3O2
Molecular Weight	~1440.5 g/mol (Free base), ~1554.5 g/mol (as TFA salt)
Synonyms	N-Methylanthraniloyl-Amyloid β-Protein (37-44)-Lys(Dnp)-D-Arg-D-Arg-D-Arg-NH2 TFA Salt; Aβ(37-44) (Lys(Dnp)-D-Arg-D-Arg-D-Arg) N-Me-Abz Modified Peptide; Amyloid Beta Peptide Fragment 37-44 Derivative; Dnp-Labeled, D-Arginine-rich Aβ(37-44) Analog; H₂N-VGGVVIA-Lys(Dnp)-dArg-dArg-dArg-CONH₂ (N-terminal Me-Abz); CAS 600728-90-3; Custom Fluorescent/Quenched Peptide Substrate
EINECS	Contact for details

Quality Control

Our n-Me-Abz-Amyloid β-Protein (37-44)-Lys(Dnp)-D-Arg-D-Arg-D-Arg Amide Trifluoroacetate Salt is manufactured under strict quality systems suitable for research and development. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. Standard quality assessments include HPLC for purity determination, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, keep the container under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Amino Acid Analysis	Within ±10% of theoretical
Solubility	Soluble in DMSO, Acetonitrile/Water mixtures

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.