Description

(1R)-3α-(6-Amino-9H-Purin-9-Yl)-5α-Hydroxymethyl-1β,2α-Cyclopentanediol CAS NO 69979-46-0 is a high-purity nucleoside analog, a key intermediate in the synthesis of complex antiviral and anticancer pharmaceuticals. Its precise stereochemistry and functional groups make it a critical building block for developing targeted therapeutic agents. This compound is essential for research and production facilities in the pharmaceutical and biotechnology sectors, particularly those focused on nucleoside-based drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A vital precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Antiviral Drug Development: Used in research and production of medications targeting viral polymerases.
• Oncology Research: Serves as a key scaffold for developing chemotherapeutic agents that interfere with DNA/RNA synthesis in cancer cells.
• Biochemical Research: Employed in enzymatic studies and as a substrate or inhibitor in molecular biology assays.
• Process Chemistry: Utilized for scaling up the production of active pharmaceutical ingredients (APIs) under GMP conditions.
• Labeled Compound Synthesis: A starting material for creating isotopically labeled (e.g., C13, N15) versions for metabolic and pharmacokinetic studies.

Basic Information

Product Name	(1R)-3α-(6-Amino-9H-Purin-9-Yl)-5α-Hydroxymethyl-1β,2α-Cyclopentanediol
CAS No.	69979-46-0
Molecular Formula	C12H15N5O4
Molecular Weight	293.28 g/mol
Synonyms	9-[(1R,2S,3R,5S)-3-(Hydroxymethyl)-5-(hydroxy)-1,2-cyclopentanediol]adenine; (1R,2S,3R,5S)-3-(Hydroxymethyl)-5-(6-amino-9H-purin-9-yl)cyclopentane-1,2-diol; Carbocyclic Adenosine Intermediate; c-Ado Intermediate; 2'-Deoxycarbocyclic Adenosine Derivative; Cyclopentyl Adenine Analog; Carbocyclic Nucleoside Synthon
EINECS	Contact for details

Quality Control

Our (1R)-3α-(6-Amino-9H-Purin-9-Yl)-5α-Hydroxymethyl-1β,2α-Cyclopentanediol is manufactured under strict quality systems suitable for pharmaceutical intermediate applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure consistent quality and traceability. Comprehensive Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.