Description

Ac-Ala-α-Naphthyl Ester is a specialized protected amino acid derivative, specifically an acetylated alanine esterified with an α-naphthol group. This compound is a crucial building block and chiral intermediate in advanced organic synthesis, particularly for the preparation of peptides and complex molecules requiring specific stereochemistry. It is primarily utilized by pharmaceutical research, fine chemical synthesis, and academic research laboratories for developing novel therapeutic agents and conducting mechanistic studies.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Protease Substrate Analog: Used in biochemical research as a model substrate for studying enzyme kinetics and inhibition, particularly for proteolytic enzymes.
• Peptide Chemistry: Acts as a protected amino acid derivative in solid-phase and solution-phase peptide synthesis (SPPS).
• Asymmetric Synthesis: Employed as a chiral auxiliary or building block in stereoselective organic reactions to induce enantioselectivity.
• Fluorescent Labeling Precursor: The naphthyl group can be utilized or further modified for developing fluorescent probes and tags.
• Academic & R&D: Essential for methodological development in synthetic organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	Ac-Ala-α-Naphthyl Ester
CAS No.	69975-68-4
Molecular Formula	C₁₆H₁₇NO₃
Molecular Weight	271.31 g/mol
Synonyms	N-Acetyl-L-alanine α-naphthyl ester; Acetylalanyl α-naphthyl ester; L-Alanine, N-acetyl-, 1-naphthyl ester; N-Acetylalanine 1-naphthyl ester; Ac-Ala-ONap; 1-Naphthyl N-acetylalaninate; N-Acetyl-L-alanine 1-naphthyl ester; Alanine, N-acetyl-, 1-naphthyl ester, L-
EINECS	Contact for details

Quality Control

Our Ac-Ala-α-Naphthyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and chiral integrity, meeting the exacting standards required for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and identity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (L-isomer)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.