Description

α-(Difluoromethyl)Arginine is a specialized, non-proteinogenic amino acid derivative characterized by the presence of a difluoromethyl group on the alpha carbon of the arginine backbone. This unique structural modification makes it a valuable building block and intermediate in advanced pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel bioactive compounds, enzyme inhibitors, and fluorinated peptide analogs.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel enzyme inhibitors, particularly targeting arginine-processing enzymes.
• Biochemical Research: Used as a substrate analog in enzymatic studies to investigate reaction mechanisms and inhibition kinetics.
• Peptidomimetics: Serves as a fluorinated building block for the synthesis of modified peptides with enhanced metabolic stability or altered biological activity.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to explore the impact of fluorine substitution on drug potency and selectivity.
• Proteomics & Diagnostics: Potential use in designing activity-based probes for labeling and studying specific classes of proteases.

Basic Information

Product Name	α-(Difluoromethyl)Arginine
CAS No.	69955-43-7
Molecular Formula	C7H14F2N4O2
Molecular Weight	224.21 g/mol
Synonyms	2-Amino-5-[(diaminomethylidene)amino]-2-(difluoromethyl)pentanoic acid; (2R)-2-Amino-5-[(diaminomethylidene)amino]-2-(difluoromethyl)pentanoic acid; (R)-2-Amino-2-(difluoromethyl)-5-guanidinopentanoic acid; DFMA; α-(Difluoromethyl)arginine; (αR)-α-(Difluoromethyl)arginine; L-α-(Difluoromethyl)arginine; NSC 339313
EINECS	Contact for details

Quality Control

Our α-(Difluoromethyl)Arginine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (HPLC), and related substances is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.