Description

3-Hydroxy-5-Cholenoylglycine is a conjugated bile acid derivative, a key intermediate in the study of bile acid metabolism and synthesis. This compound matters for its role as a critical reference standard and building block in pharmaceutical research and development, particularly for liver and metabolic disorders. It is primarily needed by research institutions, pharmaceutical companies, and diagnostic manufacturers focused on hepatology, gastroenterology, and metabolic disease research. Its high purity and well-defined structure make it essential for analytical method development and biochemical studies.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and identification of bile acids in complex biological matrices via HPLC, LC-MS, or GC-MS.
• Biochemical Research: Serves as a crucial intermediate or substrate in enzymatic studies related to bile acid biosynthesis and conjugation pathways.
• Diagnostic Reagent Development: Employed in the formulation of calibration kits and assays for clinical diagnostics targeting liver function and metabolic health.
• Metabolite Studies: Utilized in metabolic profiling and biomarker discovery research to understand diseases related to cholesterol and bile acid homeostasis.
• Academic Research: A key reagent for universities and research labs investigating the molecular mechanisms of cholestasis, gallstone formation, and related digestive processes.
• Drug Discovery & Development: Acts as a precursor or analog in the synthesis of novel therapeutic agents targeting nuclear receptors like FXR (Farnesoid X receptor).

Basic Information

Product Name	3-Hydroxy-5-Cholenoylglycine
CAS No.	69776-17-6
Molecular Formula	C₂₆H₄₁NO₅
Molecular Weight	447.61 g/mol
Synonyms	Glyco-3-hydroxy-5-cholenoic acid; N-[(3α,5β)-3-Hydroxy-24-oxocholan-24-yl]glycine; 3α-Hydroxy-5β-cholan-24-oylglycine; 5β-Cholan-24-oylglycine-3α-ol; Tauro-3-hydroxy-5-cholenoic acid analog; Glycine conjugate of 3-hydroxy-5-cholenoic acid; Bile acid glycine conjugate
EINECS	Contact for details

Quality Control

Every batch of 3-Hydroxy-5-Cholenoylglycine is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our products are suitable for use as high-grade research chemicals and reference standards. A comprehensive Certificate of Analysis (COA) detailing results for assay, purity (HPLC), and identification is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation due to moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.