Description

N,N'-Bis(Trimethylsilyl)-L-Cystine Bis(Trimethylsilyl) Ester is a silylated derivative of the amino acid L-cystine, designed to enhance solubility and stability in organic synthesis. This compound is a critical reagent for protecting sensitive functional groups and facilitating peptide coupling reactions under anhydrous conditions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, biotechnology, and advanced materials sectors for the synthesis of complex peptides and modified biomolecules.

Application

• Peptide Synthesis: Acts as a protected and activated form of L-cystine for solid-phase and solution-phase peptide coupling, enabling the incorporation of disulfide bridges.
• Intermediate for API Production: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs) that contain cystine or cysteine motifs.
• Derivatization Agent: Used in analytical chemistry to silylate compounds for Gas Chromatography (GC) or Mass Spectrometry (MS) analysis, improving volatility and detection.
• Bioconjugation Chemistry: Facilitates the site-specific modification of proteins, antibodies, and other biomolecules for drug delivery and diagnostic applications.
• Material Science Research: Employed in the development of novel silicon-containing polymers and hybrid organic-inorganic materials.

Basic Information

Product Name	N,N'-Bis(Trimethylsilyl)-L-Cystine Bis(Trimethylsilyl) Ester
CAS No.	69688-44-4
Molecular Formula	C18H46N2O4S2Si4
Molecular Weight	531.06 g/mol
Synonyms	L-Cystine, N,N'-bis(trimethylsilyl)-, bis(trimethylsilyl) ester; Bis(trimethylsilyl) N,N'-bis(trimethylsilyl)-L-cystinate; Hexakis(trimethylsilyl) L-cystine; Silylated L-Cystine; TMS-Cystine(TMS)4; N,N',O,O'-Tetrakis(trimethylsilyl)-L-cystine
EINECS	Contact for details

Quality Control

Our N,N'-Bis(Trimethylsilyl)-L-Cystine Bis(Trimethylsilyl) Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our customers in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep the container tightly sealed in a desiccator when not in use.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.