Description

(S)-2-Amino-3-(1-Methyl-1H-Imidazol-4-Yl)-Propionic Acid 2Hcl is a high-purity, non-proteinogenic amino acid derivative, specifically the dihydrochloride salt of L-Histidine methylated at the imidazole nitrogen. This compound is a critical chiral building block for advanced pharmaceutical research and development, offering a protected histidine analog for peptide synthesis. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for creating novel therapeutic peptides and investigating enzyme-substrate interactions.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of complex peptide-based active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate a modified histidine residue, influencing peptide structure and bioactivity.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies and for probing histidine-related biological pathways.
• Ligand Development: Acts as a precursor for developing chelating agents or metal-binding motifs in medicinal chemistry.
• Reference Standard: Supplied as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	(S)-2-Amino-3-(1-Methyl-1H-Imidazol-4-Yl)-Propionic Acid 2Hcl
CAS No.	69614-06-8
Molecular Formula	C7H11N3O2 · 2HCl
Molecular Weight	266.10 g/mol
Synonyms	L-1-Methylhistidine dihydrochloride; (S)-1-Methyl-L-histidine 2HCl; 1-Methyl-L-histidine dihydrochloride; (S)-2-Amino-3-(1-methyl-1H-imidazol-5-yl)propanoic acid dihydrochloride; 1-Methylhistidine HCl; 3-(1-Methyl-1H-imidazol-4-yl)-L-alanine dihydrochloride; 1-MH 2HCl
EINECS	Contact for details

Quality Control

Our (S)-2-Amino-3-(1-Methyl-1H-Imidazol-4-Yl)-Propionic Acid 2Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the stringent requirements for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specified standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions. For long-term storage, consider desiccated environments.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.