Description

α-Endorphin, Des-Tyr(1)- is a specific, truncated form of the endogenous opioid peptide α-endorphin. This compound is of significant value in biochemical and pharmacological research for studying opioid receptor subtypes and signal transduction pathways without the full biological activity profile of the parent peptide. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic manufacturers focused on neuroscience, pain management, and neuroendocrine regulation.

Application

• Neuroscience Research: Used as a reference standard and tool compound for investigating the structure-activity relationships (SAR) of opioid peptides and their fragments.
• Receptor Binding Assays: Serves as a ligand or competitor in in vitro assays to characterize binding affinities to delta (δ) and mu (μ) opioid receptors.
• Biochemical Standard: Acts as a high-purity calibrant or control in analytical techniques such as HPLC and mass spectrometry for peptide analysis.
• Pharmaceutical Development: Employed in early-stage drug discovery programs targeting the opioid system for pain, addiction, or mood disorders.
• Academic Studies: Facilitates fundamental research on endorphin metabolism, peptide processing, and the physiological roles of peptide fragments.

Basic Information

Product Name	α-Endorphin, Des-Tyr(1)-
CAS No.	69460-01-1
Molecular Formula	C76H122N20O22S
Molecular Weight	1683.97 g/mol
Synonyms	Des-Tyr¹-α-Endorphin; α-Endorphin (2-16); β-Lipotropin (61-76); LPH (61-76); [Des-Tyrosine¹]-α-Endorphin; H-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-OH; α-Endorphin fragment 2-16
EINECS	Contact for details

Quality Control

Our α-Endorphin, Des-Tyr(1)- is manufactured under controlled conditions to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and mass spectrometry for identity confirmation. Certificates of Analysis (COA) detailing all quality parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.