Description

Cobratoxin CAS NO 69344-74-7 is a potent neurotoxic peptide isolated from the venom of the cobra (Naja naja atra). This highly specific compound is a valuable research tool for studying nicotinic acetylcholine receptors (nAChRs) and neuronal signaling pathways. It is essential for researchers and developers in the fields of neuroscience, pharmacology, and toxicology who require high-purity, biologically active toxins for receptor characterization, assay development, and drug discovery.

Application

• Neuroscience Research: As a selective antagonist for muscle-type and neuronal nicotinic acetylcholine receptors, used to study receptor function, distribution, and signaling mechanisms.
• Pharmacological Studies: Employed in competitive binding assays and functional studies to evaluate the potency and mechanism of action of new therapeutic candidates targeting nAChRs.
• Toxicology & Venom Research: Serves as a reference standard for analyzing cobra venom composition and for developing antivenoms and therapeutic countermeasures.
• Biochemical Reagent: Used in the purification and isolation of acetylcholine receptors via affinity chromatography techniques.
• Ion Channel Characterization: A critical tool for electrophysiology studies, helping to characterize ion channel kinetics and blockades.
• Drug Discovery Platforms: Integrated into high-throughput screening (HTS) assays to identify novel modulators of nicotinic receptor activity.

Basic Information

Product Name	Cobratoxin
CAS No.	69344-74-7
Molecular Formula	C185H285N55O57S7
Molecular Weight	~7823.0 g/mol
Synonyms	Cobrotoxin; Naja naja atra toxin; α-Cobratoxin; Long Neurotoxin 1; CTX; Cobra Neurotoxin; α-Neurotoxin; Acetylcholine Receptor Antagonist; UNII-5SZZ6J2R8M
EINECS	Contact for details

Quality Control

Our Cobratoxin is produced under stringent conditions to ensure the highest levels of purity and biological activity, suitable for critical research applications. Each batch is characterized by advanced analytical techniques including HPLC, mass spectrometry, and amino acid analysis. A comprehensive Certificate of Analysis (COA) detailing purity, potency (LD50), and endotoxin levels is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store lyophilized powder at -20°C or below. For long-term storage, keep desiccated at -70°C. Reconstituted solutions should be aliquoted and stored at -20°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Potency (LD50, mouse)	0.07 - 0.12 µg/g (intravenous)
Protein Content (Biuret)	≥ 90%
Endotoxin Level (LAL)	< 10 EU/mg
Solubility	Soluble in water or saline

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.