Description

H-Thr-Otbu Hcl CAS NO 69320-90-7 is a protected amino acid derivative, specifically the hydrochloride salt of O-tert-butyl-L-threonine. This compound is a critical building block in peptide synthesis, offering a protected side chain that prevents unwanted reactions during the coupling process. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require high-purity intermediates for the development of novel therapeutic peptides and active pharmaceutical ingredients (APIs).

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of threonine residues into peptide chains.
• Solution-Phase Peptide Synthesis: Used in classical solution methods for constructing complex peptide sequences.
• Pharmaceutical Research: Serves as a building block for the research and development of peptide-based drugs, hormones, and vaccines.
• Bioconjugation: Utilized in the chemical modification of proteins and other biomolecules for diagnostic or therapeutic purposes.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive compounds.
• Academic & Industrial R&D: A fundamental reagent for synthetic chemistry research focused on peptide mimetics and molecular probes.

Basic Information

Item	Detail
Product Name	H-Thr-Otbu Hcl
CAS No.	69320-90-7
Molecular Formula	C8H18ClNO3
Molecular Weight	211.69 g/mol
Synonyms	O-tert-Butyl-L-threonine hydrochloride; L-Threonine, O-(1,1-dimethylethyl)-, hydrochloride (1:1); H-Thr(tBu)-OH·HCl; (2S,3R)-2-Amino-3-[(2-methylpropan-2-yl)oxy]butanoic acid hydrochloride; Boc-Thr(tBu)-OH (related protected form); Fmoc-Thr(tBu)-OH (related protected form); Thr(OtBu) hydrochloride; tert-Butyl L-threoninate hydrochloride
EINECS	Contact for details

Quality Control

Our H-Thr-Otbu Hcl is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation by IR and NMR spectroscopy. We provide Certificates of Analysis (COA) with every shipment, detailing all specifications and test results to ensure compliance with your research or cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]	Contact for details
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.2%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.