Description

L-Isoleucine tert-Butyl Ester Hydrochloride is a protected amino acid derivative essential for advanced organic synthesis. This compound is a critical chiral building block, valued for its role in constructing complex peptides and bioactive molecules with high stereochemical purity. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, process development, and the synthesis of specialized fine chemicals.

Application

• Pharmaceutical Intermediates: A key chiral synthon in the synthesis of peptide-based drugs, protease inhibitors, and other active pharmaceutical ingredients (APIs).
• Peptide Synthesis (SPPS & Solution Phase): Used as a protected amino acid component to introduce the L-isoleucine residue while preventing unwanted side reactions.
• Biochemical Research: Employed in the study of enzyme-substrate interactions, metabolic pathways, and the structure-activity relationships of peptides.
• Fine Chemical Production: Serves as a precursor in the manufacture of complex organic molecules for agrochemicals, diagnostics, and material science.
• Process Chemistry & Scale-Up: Provides a reliable and high-purity starting material for the development and optimization of commercial-scale synthetic routes.

Basic Information

Product Name	L-Isoleucine tert-Butyl Ester Hydrochloride
CAS No.	69320-89-4
Molecular Formula	C10H22ClNO2
Molecular Weight	223.74 g/mol
Synonyms	L-Isoleucine tert-butyl ester HCl; (2S,3S)-2-Amino-3-methylpentanoic acid 1,1-dimethylethyl ester hydrochloride; H-Ile-OtBu·HCl; tert-Butyl L-isoleucinate hydrochloride; (S,S)-Isoleucine tert-butyl ester hydrochloride; L-Ile-OtBu·HCl; Boc-Ile-OtBu (Note: Boc-protected variant is different); Isoleucine t-butyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our L-Isoleucine tert-Butyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.