Description

(R)-Baclofen CAS NO 69308-37-8 is the pharmacologically active enantiomer of the muscle relaxant Baclofen, a γ-aminobutyric acid (GABA) derivative. This high-purity chiral intermediate is critical for the research and development of targeted neurological therapeutics with enhanced efficacy and reduced side-effect profiles. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers specializing in active pharmaceutical ingredients (APIs) for central nervous system disorders.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Key chiral building block for the production of enantiopure (R)-Baclofen API.
• Neurological Research: Used as a reference standard and investigational compound in studies targeting GABAB receptor function.
• Preclinical Development: Serves as a critical material for pharmacokinetic, pharmacodynamic, and toxicology studies for new drug candidates.
• Process Chemistry & Optimization: Employed in the development and scaling of asymmetric synthesis routes for GABA analogs.
• Analytical Standard: High-purity material for HPLC, LC-MS, and chiral analysis method development and validation.
• Pharmaceutical Intermediates: Manufacture of advanced intermediates for novel spasticity and pain management therapies.

Basic Information

Product Name	(R)-Baclofen
CAS No.	69308-37-8
Molecular Formula	C10H12ClNO2
Molecular Weight	213.66 g/mol
Synonyms	(R)-(-)-Baclofen; (3R)-4-Amino-3-(4-chlorophenyl)butanoic acid; (R)-4-Amino-3-(4-chlorophenyl)butyric acid; (R)-Baclofen; (-)-Baclofen; R-Baclofen; Baclofen R-isomer; Lioresal (R-enantiomer)
EINECS	Contact for details

Quality Control

Our (R)-Baclofen is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is hygroscopic and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.