Description

C18 Globotriaosylceramide (D18:1/18:0) is a high-purity, well-defined glycosphingolipid (GSL) standard, critical for research in lipidomics and glycolipid biology. This compound serves as an essential reference material for the accurate identification and quantification of globo-series glycosphingolipids in complex biological samples. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, diagnostic, and life science sectors for biomarker discovery, assay development, and metabolic disease research.

Application

• Biomarker Research & Diagnostic Assay Development: Used as a reference standard for detecting and quantifying Gb3 (globotriaosylceramide) in plasma, urine, or tissue samples, relevant for Fabry disease screening and monitoring.
• Lipidomics & Metabolomics: Serves as a critical internal or external standard in mass spectrometry-based lipidomic profiling to ensure analytical accuracy and reproducibility.
• Enzyme Activity Studies: Employed as a substrate for in vitro assays to study the activity of enzymes like α-galactosidase A, which is deficient in Fabry disease.
• Cell Biology & Signaling Research: Used to investigate the role of globo-series GSLs in cell membrane structure, pathogen recognition (e.g., Shiga toxin binding), and cellular signaling pathways.
• Pharmaceutical Quality Control: Acts as a purity standard in the development and validation of therapeutic products targeting glycosphingolipid storage disorders.
• Reference Material Production: Sourced by manufacturers of certified reference materials (CRMs) and diagnostic kits requiring high-purity lipid components.

Basic Information

Item	Details
Product Name	C18 Globotriaosylceramide (D18:1/18:0)
CAS No.	69283-33-6
Molecular Formula	C60H115NO13
Molecular Weight	1058.57 g/mol
Synonyms	Gb3 (d18:1/18:0); Globotriaosylceramide (d18:1/18:0); CD77; Gal(α1-4)Gal(β1-4)Glc(β1-1')Cer(d18:1/18:0); Pk antigen; Ceramide trihexoside (CTH, specific isomer); Globotriaosylceramide (C18:0); 1-O-[α-D-Galactopyranosyl-(1→4)-β-D-galactopyranosyl-(1→4)-β-D-glucopyranosyl]-N-octadecanoylsphing-4-enine
EINECS	Contact for details

Quality Control

Every batch of C18 Globotriaosylceramide (D18:1/18:0) is produced and analyzed under strict quality management protocols. Our products undergo rigorous identity confirmation and purity testing using advanced analytical techniques such as HPLC, MS, and NMR to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA), detailing batch-specific purity, identity, and impurity profiles, is available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep desiccated under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 2.0 %
Solubility	Soluble in chloroform/methanol mixtures, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.