Description

tert-Butyloxycarbonyl-Phenylalanyl-Prolyl-Arginal is a high-purity, synthetic peptide derivative featuring a C-terminal arginal (arginine aldehyde) residue, which functions as a potent and selective inhibitor of serine proteases. This compound is of significant value in biochemical research and pharmaceutical development due to its role as a key intermediate and active site probe. It is primarily utilized by researchers and manufacturers in the fields of protease inhibitor design, medicinal chemistry, and peptide-based drug discovery.

Application

• Biochemical Research: As a critical tool compound for studying the mechanism and inhibition of trypsin-like serine proteases.
• Pharmaceutical Intermediates: Serves as a key building block in the synthesis of more complex protease inhibitor candidates for therapeutic applications.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies to optimize the potency and selectivity of inhibitor leads.
• Enzyme Profiling: Employed in assays to characterize and validate the specificity profiles of various proteases.
• Academic Research: Fundamental studies on blood coagulation, fibrinolysis, and other physiological processes involving serine proteases.

Basic Information

Product Name	tert-Butyloxycarbonyl-Phenylalanyl-Prolyl-Arginal
CAS No.	69201-89-4
Molecular Formula	C24H36N6O5
Molecular Weight	488.58 g/mol
Synonyms	Boc-Phe-Pro-Arg-H; Boc-Phenylalanyl-Prolyl-Argininal; BOC-PHE-PRO-ARG-H; (2S)-5-[[(2S)-1-[[(2S)-2-[[(2-methylpropan-2-yl)oxycarbonyl]amino]-3-phenylpropanoyl]pyrrolidin-2-yl]formamido]-2-(diaminomethylideneamino)pentanal; Thrombin Inhibitor I; Protease Inhibitor (Arginal-based); Nα-Boc-L-phenylalanyl-L-prolyl-L-argininal
EINECS	Contact for details

Quality Control

Our tert-Butyloxycarbonyl-Phenylalanyl-Prolyl-Arginal is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.