Description

(6S)-5,6,7,8-Tetrahydro-L-Erythro-Biopterin Dihydrochloride is a high-purity, biologically active form of tetrahydrobiopterin (BH4), a critical cofactor for aromatic amino acid hydroxylases and nitric oxide synthases. This compound is essential for research and development in neuroscience, metabolic disorders, and cardiovascular function studies. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of diagnostic reagents and high-value biochemicals.

Application

• Pharmaceutical Research & Development: As a reference standard and active ingredient in studies targeting phenylketonuria (PKU), dopamine-related disorders, and endothelial dysfunction.
• Enzyme Cofactor Studies: Essential for in vitro assays of enzymes like phenylalanine hydroxylase (PAH), tyrosine hydroxylase (TH), and nitric oxide synthase (NOS).
• Diagnostic Reagent Manufacturing: Used in the production of kits for the diagnosis of BH4 deficiency and related metabolic conditions.
• Cell Culture & Neuroscience: Supports cell growth and function in specialized neuronal and endothelial cell culture applications.
• Biochemical Synthesis: Serves as a key intermediate or precursor in the synthesis of more complex biochemical compounds and probes.

Basic Information

Product Name	(6S)-5,6,7,8-Tetrahydro-L-Erythro-Biopterin Dihydrochloride
CAS No.	69056-39-9
Molecular Formula	C9H17N5O3 · 2HCl
Molecular Weight	320.18 g/mol (Free base: 247.27)
Synonyms	(6R,S)-5,6,7,8-Tetrahydro-L-biopterin Dihydrochloride; (6S)-BH4 Dihydrochloride; 6R-THBP Dihydrochloride; Sapropterin Dihydrochloride (stereoisomer); L-Erythro-Tetrahydrobiopterin Dihydrochloride; 2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(1H)-one Dihydrochloride; 6,7-Dihydropterin Dihydrochloride Derivative
EINECS	Contact for details

Quality Control

Our (6S)-5,6,7,8-Tetrahydro-L-Erythro-Biopterin Dihydrochloride is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR, to ensure it meets the stringent requirements for research and development applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]20/D: Contact for details
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.