Description

Angiotensin II, 1-Sar-7-Sar-8-Ile- is a synthetic peptide analog of the endogenous hormone angiotensin II, featuring specific amino acid substitutions at positions 1 and 7 with sarcosine (Sar) and at position 8 with isoleucine (Ile). This modification is designed to enhance its stability and receptor-binding profile, making it a critical research tool for studying the renin-angiotensin system (RAS). It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on cardiovascular physiology, hypertension, and drug discovery.

Application

• Biomedical Research: Used as a reference standard and agonist in studies of angiotensin II receptor (AT1 and AT2) signaling pathways.
• Drug Discovery & Development: Serves as a key pharmacological tool for screening and validating potential antihypertensive drug candidates and receptor antagonists.
• In Vitro Assays: Employed in cell-based assays to investigate vascular contraction, aldosterone secretion, and other physiological responses mediated by the RAS.
• Academic Studies: Facilitates fundamental research in cardiovascular biology, endocrinology, and peptide hormone action.
• Biochemical Reagent: Acts as a specific ligand in receptor binding studies and competitive inhibition experiments.
• Quality Control: Utilized as an analytical reference standard for the identification and quantification of related peptide compounds.

Basic Information

Product Name	Angiotensin II, 1-Sar-7-Sar-8-Ile-
CAS No.	68941-19-5
Molecular Formula	C₄₉H₇₀N₁₄O₁₁
Molecular Weight	1031.2 g/mol
Synonyms	[Sar¹,Ile⁸]-Angiotensin II; Sarile; [Sar¹, Ile⁸]-Ang II; 1-Sarcosine,8-Isoleucine Angiotensin II; Angiotensin II Sar¹ Ile⁸; Angiotensin II (1-8) Sar¹ Ile⁸; Angiotensin II analogue (Sar¹, Ile⁸); H-Sar-Arg-Val-Tyr-Ile-His-Pro-Ile-OH
EINECS	Contact for details

Quality Control

Our Angiotensin II, 1-Sar-7-Sar-8-Ile- is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and mass spectrometry for identity confirmation, to ensure it meets the high standards required for research applications. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.