Description

6-(Trifluoromethyl)-2,3-Dihydro-1H-Inden-1-Amine CAS NO 68755-40-8 is a specialized organic compound featuring a fused indane core substituted with a trifluoromethyl group and a primary amine functionality. This unique structure makes it a valuable and versatile building block (synthon) in advanced organic synthesis, particularly for introducing the highly desirable trifluoromethyl pharmacophore. It is primarily utilized by pharmaceutical research and agrochemical development teams seeking to create novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially in central nervous system (CNS) and oncology research, where the trifluoromethyl group can improve lipophilicity and binding affinity.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging the fluorine atoms to enhance biological activity and environmental persistence.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of specialty polymers, liquid crystals, or organic electronic materials with unique properties.
• Chemical Biology & Proteomics: Employed as a scaffold or labeling reagent for probing biological systems and developing chemical probes.
• Catalyst & Ligand Development: The amine group allows for complexation with metals, making it useful for designing novel chiral ligands or organocatalysts for asymmetric synthesis.
• Fluorine Chemistry Library Building: An essential component for constructing diverse compound libraries focused on fluorine-containing molecules for high-throughput screening in drug discovery.

Basic Information

Product Name	6-(Trifluoromethyl)-2,3-Dihydro-1H-Inden-1-Amine
CAS No.	68755-40-8
Molecular Formula	C10H10F3N
Molecular Weight	201.19 g/mol
Synonyms	6-(Trifluoromethyl)-2,3-dihydro-1H-inden-1-amine; 1-Amino-6-(trifluoromethyl)indane; 6-(Trifluoromethyl)indan-1-amine; 6-Trifluoromethyl-1-indanamine; 1-Indanamine, 6-(trifluoromethyl)-; 6-Trifluoromethylindan-1-ylamine; 6-CF3-indan-1-amine; 6-(Trifluoromethyl)-1-aminoindane
EINECS	Contact for details

Quality Control

Our production of 6-(Trifluoromethyl)-2,3-Dihydro-1H-Inden-1-Amine adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research and development applications. All batches are fully characterized using advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.