Description

Ethyl L-Histidinate Hydrochloride is a protected derivative of the essential amino acid L-Histidine, widely utilized in peptide synthesis and pharmaceutical research. This compound serves as a crucial building block for creating complex peptides and peptidomimetics, offering enhanced stability and solubility during coupling reactions. It is primarily sought by research institutions, pharmaceutical developers, and fine chemical manufacturers engaged in the production of bioactive peptides, diagnostic agents, and novel therapeutic candidates.

Application

• Peptide Synthesis: A key protected amino acid derivative for solid-phase and solution-phase peptide synthesis (SPPS).
• Pharmaceutical Intermediates: Serves as a critical building block in the research and development of peptide-based drugs and APIs.
• Biochemical Research: Used in enzymatic studies, substrate modeling, and the investigation of histidine-related metabolic pathways.
• Diagnostic Reagent Production: Employed in the manufacture of specialized reagents and labeled compounds for diagnostic assays.
• Cosmetic Peptides: A potential ingredient in the synthesis of bioactive peptides for advanced skincare and cosmetic formulations.

Basic Information

Product Name	Ethyl L-Histidinate Hydrochloride
CAS No.	68636-91-9
Molecular Formula	C8H16N3O2•HCl
Molecular Weight	231.69 g/mol (Free base: 186.23)
Synonyms	L-Histidine ethyl ester dihydrochloride; H-His-OEt•HCl; Ethyl L-histidinate dihydrochloride; Histidine ethyl ester hydrochloride; (S)-2-Amino-3-(1H-imidazol-4-yl)propanoic acid ethyl ester hydrochloride; Ethyl (2S)-2-amino-3-(1H-imidazol-5-yl)propanoate hydrochloride; Ethyl α-amino-1H-imidazole-4-propanoate hydrochloride
EINECS	Contact for details

Quality Control

Our Ethyl L-Histidinate Hydrochloride is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR. We provide full traceability and Certificates of Analysis (COA) are available for all shipments to ensure compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]	Contact for details
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.