Description

Disuccinimidyl Suberate is a homobifunctional, amine-reactive crosslinking agent featuring an extended 8-atom spacer arm. This compound is critical for creating stable covalent bonds between primary amines in proteins, peptides, and other biomolecules, enabling advanced structural and functional studies. It is an essential reagent for researchers and manufacturers in bioconjugation, antibody-drug conjugate (ADC) development, and proteomics, where precise and reliable crosslinking is paramount.

Application

• Bioconjugation and Protein Crosslinking: Primary reagent for conjugating antibodies, enzymes, and other proteins to labels, surfaces, or other proteins.
• Antibody-Drug Conjugate (ADC) Development: Used as a linker to attach cytotoxic payloads to monoclonal antibodies, a key step in targeted cancer therapy.
• Immobilization Chemistry: Functionalizing solid supports (e.g., beads, plates, biosensors) with proteins or peptides for assay development and purification.
• Structural Biology and Proteomics: Studying protein-protein interactions, complex formation, and mapping spatial relationships within macromolecular assemblies.
• Diagnostic Reagent Manufacturing: Production of stable, conjugated reagents for immunoassays and clinical diagnostics.
• Materials Science: Crosslinking amine-containing polymers or modifying material surfaces for biomedical and biotechnological applications.

Basic Information

Product Name	Disuccinimidyl Suberate
CAS No.	68526-60-3
Molecular Formula	C20H28N2O8
Molecular Weight	424.45 g/mol
Synonyms	DSS; Suberic Acid Bis(N-succinimidyl) Ester; Bis(N-succinimidyl) Suberate; N,N'-Disuccinimidyl Suberate; Disuccinimidyl Octanedioate; BS3 (homobifunctional analog); Bis(succinimidyl) Suberate; 3,3'-Dithiobis(sulfosuccinimidyl propionate) homobifunctional analog (non-sulfonated)
EINECS	Contact for details

Quality Control

Our Disuccinimidyl Suberate is manufactured under strict quality systems to ensure batch-to-batch consistency and high performance in sensitive applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and functional activity validation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term stability, store under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile
Functional Activity	Conforms (by amine coupling test)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.