Description

Thiopropyl-Activated Matrix is a functionalized solid support designed for the covalent immobilization of thiol-containing biomolecules via disulfide bond formation. This product is essential for researchers and manufacturers requiring a stable, high-capacity platform for affinity chromatography, protein purification, and bioconjugation. It is particularly valuable for the production of antibody-drug conjugates (ADCs), enzyme immobilization, and the development of diagnostic assays in the biopharmaceutical and life sciences sectors.

Application

• Affinity Chromatography Media: For the purification of antibodies, recombinant proteins, and other thiol-containing biomolecules.
• Bioconjugation & Immobilization: Covalent attachment of enzymes, peptides, or oligonucleotides for biosensor development and diagnostic test kits.
• Antibody-Drug Conjugate (ADC) Development: Serves as a critical intermediate or tool for site-specific conjugation in therapeutic linker-payload attachment.
• Solid-Phase Synthesis Support: Used in peptide and oligonucleotide synthesis where a reversible disulfide linkage is required.
• Drug Delivery Systems: Fabrication of targeted delivery vehicles where controlled release via disulfide cleavage is desired.
• Research & Development: A key reagent in biochemical research for studying protein-protein interactions and ligand binding.

Basic Information

Product Name	Thiopropyl-Activated Matrix
CAS No.	68517-67-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	2-Thiopyridyl-activated agarose; Activated Thiol Sepharose; Thiopropyl Sepharose; 2-Pyridyldithio-activated matrix; PDP-Activated Matrix; 2-Pyridyldisulfanylpropyl-activated support; Thiol-reactive chromatography medium; Disulfide coupling gel
EINECS	Contact for details

Quality Control

Our Thiopropyl-Activated Matrix is manufactured under a strict quality management system. Each batch is tested to ensure consistent performance, including parameters such as ligand density, active group availability, and particle size distribution. A Certificate of Analysis (COA) detailing the specific results is provided with every shipment to guarantee traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., nitrogen) to prevent oxidation and maintain reactivity. Avoid exposure to moisture and elevated temperatures.

Specification

Item	Specification
Appearance	White to off-white beads (slurry)
Matrix	Cross-linked agarose
Particle Size	45-165 μm (or as specified)
Ligand Density	10-40 μmol/mL gel (Contact for specific grade)
Active Group	2-Pyridyldithiopropyl
Capacity	>15 mg human IgG/mL gel (typical)
Storage Buffer	20% Ethanol
pH Stability	2-11 (working range)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.