Description

Glutamate-1-Semialdehyde is a key biochemical intermediate in the biosynthesis of tetrapyrroles, including chlorophyll and heme. Its role as a precursor makes it a critical compound for research in plant physiology, microbiology, and metabolic pathway analysis. This high-purity intermediate is essential for biochemical studies, enzymatic assays, and the development of biosynthetic processes in the life science and agricultural biotechnology sectors.

Application

• Biochemical Research: Used as a pivotal intermediate in studying the C5 pathway for tetrapyrrole biosynthesis.
• Enzymology Studies: Serves as a substrate for glutamate-1-semialdehyde aminotransferase (GSAT) in enzyme kinetics and mechanism research.
• Plant Physiology & Agriculture: Investigated for its role in chlorophyll synthesis, relevant for studies on plant growth, photosynthesis, and herbicide development.
• Microbial Metabolism: Utilized in research on heme and vitamin B12 biosynthesis in bacteria and algae.
• Pharmaceutical Precursor Research: Explored in the development of porphyrin-based compounds for therapeutic applications.
• Diagnostic Reagent Development: Potential use in formulating reagents for enzymatic diagnostic kits.
• Metabolic Engineering: A key building block in engineered pathways for the microbial production of valuable tetrapyrroles.
• Reference Standard: Employed as a high-purity analytical standard in chromatography (HPLC, LC-MS) for quality control and method validation.

Basic Information

Product Name	Glutamate-1-Semialdehyde
CAS No.	68462-55-5
Molecular Formula	C5H7NO4
Molecular Weight	145.11 g/mol
Synonyms	L-Glutamate-1-semialdehyde; (S)-2-Amino-5-oxopentanoic acid; 2-Aminoglutaric semialdehyde; Glutamic acid-1-semialdehyde; GSA; 1-Semialdehyde glutamic acid; 5-Oxo-L-norvaline; Aminoglutaric semialdehyde
EINECS	Contact for details

Quality Control

Our Glutamate-1-Semialdehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation. The product is easily oxidized; prolonged exposure to air or elevated temperatures should be avoided. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 90% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.