Description

3-[2-(2-Maleimidoethoxy)Ethylcarbamoyl]-Proxyl is a specialized spin-labeling reagent featuring a maleimide functional group for selective conjugation to thiol groups. This bifunctional molecule is critical for probing protein structure, dynamics, and interactions using Electron Paramagnetic Resonance (EPR) spectroscopy. It is primarily utilized by researchers and developers in the fields of structural biology, biophysics, and pharmaceutical development for site-directed spin labeling studies.

Application

• Site-Directed Spin Labeling (SDSL) for EPR spectroscopy to study protein conformation and dynamics.
• Structural Biology Research, including the investigation of protein folding, unfolding, and macromolecular interactions.
• Membrane Protein Studies, enabling the labeling of cysteine residues in complex lipid environments.
• Drug Discovery & Development, as a tool to characterize target-ligand binding events and conformational changes.
• Bioconjugation & Probe Development for creating labeled antibodies, enzymes, or other biomolecules for analytical assays.
• Material Science, for modifying polymer or nanoparticle surfaces with stable nitroxide radicals.

Basic Information

Product Name	3-[2-(2-Maleimidoethoxy)Ethylcarbamoyl]-Proxyl
CAS No.	68407-07-8
Molecular Formula	C15H22N3O5
Molecular Weight	324.36 g/mol
Synonyms	3-Maleimido-PROXYL; Maleimido-Proxyl; 3-Maleimido-2,2,5,5-tetramethyl-1-pyrrolidinyloxy; 3-Maleimidopropyl proxyl; 3-Maleimido-2,2,5,5-tetramethylpyrrolidine-1-oxyl; 1-Oxyl-2,2,5,5-tetramethyl-3-pyrrolidinyl maleimide; PROXYL maleimide; MTSSL analog
EINECS	Contact for details

Quality Control

Our 3-[2-(2-Maleimidoethoxy)Ethylcarbamoyl]-Proxyl is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and stability parameters. We support compliance with relevant research and development standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. Desiccate if stored for extended periods. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Orange to red solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Solubility	Soluble in DMSO, DMF, acetonitrile
EPR Signal	Characteristic triplet spectrum

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.