Description

(S)-4'-Hydroxy Warfarin CAS NO 68407-05-6 is a specific stereoisomer of a key hydroxylated metabolite of the anticoagulant drug warfarin. This compound is of significant value in pharmaceutical research and development, particularly for metabolic and pharmacokinetic studies. It serves as a critical reference standard and intermediate for analytical method development and impurity profiling. Industries requiring this high-purity chiral compound include pharmaceutical R&D, contract research organizations (CROs), and analytical laboratories focused on cardiovascular and anticoagulant therapies.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and identification of warfarin metabolites in biological matrices and drug formulations.
• Metabolic Pathway Research: Essential for in vitro and in vivo studies investigating the stereoselective metabolism and pharmacokinetics of warfarin.
• Impurity Profiling: Serves as a known impurity standard in the quality control of warfarin active pharmaceutical ingredients (APIs) to ensure compliance with ICH guidelines.
• Analytical Method Development: A critical component for developing and validating sensitive HPLC, LC-MS, or GC-MS methods for metabolite detection.
• Biochemical Research: Used in studies exploring the structure-activity relationships (SAR) and enzyme interactions of vitamin K antagonists.
• Drug-Drug Interaction Studies: Employed in research assessing how other drugs affect the metabolic clearance of warfarin.

Basic Information

Product Name	(S)-4'-Hydroxy Warfarin
CAS No.	68407-05-6
Molecular Formula	C19H16O6
Molecular Weight	340.33 g/mol
Synonyms	(S)-4'-Hydroxywarfarin; (S)-7-Hydroxywarfarin; (3S)-4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one; Warfarin, 4'-hydroxy-, (S)-; 2H-1-Benzopyran-2-one, 4-hydroxy-3-[(1S)-3-oxo-1-phenylbutyl]-; 4'-Hydroxywarfarin (S-enantiomer); (S)-3-(α-Acetonyl-4-hydroxybenzyl)-4-hydroxycoumarin
EINECS	Contact for details

Quality Control

Our (S)-4'-Hydroxy Warfarin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chromatographic data is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (S-enantiomer)
Related Substances (HPLC)	Total impurities ≤2.0%
Solubility	Soluble in DMSO, methanol; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.