Description

Somatostatin, Octapeptide-Trp(8)- CAS NO 68374-47-0 is a synthetic octapeptide analog of the endogenous hormone somatostatin, characterized by a tryptophan substitution at the 8th position. This modification enhances its receptor binding affinity and metabolic stability, making it a critical research tool for studying somatostatin receptor (SSTR) signaling pathways. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in endocrinology, oncology, and neurobiology research.

Application

• Biomedical Research: A key reference standard and pharmacological tool for investigating the function and distribution of somatostatin receptors (SSTRs) in vitro and in vivo.
• Drug Discovery & Development: Used in high-throughput screening (HTS) assays to identify and characterize novel SSTR-targeting therapeutics for conditions like acromegaly and neuroendocrine tumors.
• Receptor Binding Studies: Essential for competitive binding assays to determine the affinity (Ki/IC50) of new chemical entities for various SSTR subtypes.
• Signal Transduction Research: Employed to study the inhibition of hormone secretion (e.g., growth hormone, insulin, glucagon) and cellular proliferation pathways.
• Peptide Chemistry & Analog Synthesis: Serves as a core structure or intermediate for the synthesis of more potent or selective somatostatin analogs.
• Diagnostic Agent Development: Acts as a precursor or conjugate for developing radiolabeled (e.g., with 68Ga, 111In) probes for positron emission tomography (PET) or single-photon emission computed tomography (SPECT) imaging.

Basic Information

Product Name	Somatostatin, Octapeptide-Trp(8)- CAS NO 68374-47-0
CAS No.	68374-47-0
Molecular Formula	C49H66N12O10S2
Molecular Weight	1023.2 g/mol
Synonyms	Octapeptide-Trp(8)-Somatostatin; H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH (cyclic 3-14 disulfide); Somatostatin (1-14), 8-L-Tryptophan-; [Trp8]-Somatostatin-14; SRIF-14 (Trp8); SMS 201-995 precursor analog; L-363,301 (research code)
EINECS	Contact for details

Quality Control

Our Somatostatin, Octapeptide-Trp(8)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the exacting standards required for research and development. Certificates of Analysis (COA) detailing purity (by HPLC), peptide content, amino acid analysis, and mass spectrometry (MS) data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store desiccated under an inert atmosphere. Allow the vial to reach room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular ion peak [M+H]+ consistent with theoretical mass
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by amino acid analysis)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.