Description

Substance P (1-6) CAS NO 68232-52-0 is a bioactive hexapeptide fragment derived from the full-length neuropeptide Substance P. This specific sequence is critical for research into neurokinin-1 (NK-1) receptor interactions and signal transduction pathways. It serves as an essential tool compound for neuroscientists and pharmacologists studying pain, inflammation, and neurotransmission. Key industrial users include pharmaceutical R&D laboratories, academic research institutions, and biotech companies focused on neurological and inflammatory disorders.

Application

• Neuroscience Research: Used as a selective ligand to study the binding affinity and function of the NK-1 receptor in central and peripheral nervous systems.
• Pharmacological Assay Development: Serves as a reference standard and active agent in high-throughput screening (HTS) for novel analgesic or anti-inflammatory drug candidates.
• Cell Signaling Studies: Applied in vitro to investigate intracellular calcium mobilization and other downstream effects mediated by Substance P receptor activation.
• Biochemical Tool: Utilized in enzyme-linked immunosorbent assays (ELISAs), radioimmunoassays (RIAs), and other analytical methods for peptide quantification and characterization.
• Academic & Clinical Research: Supports fundamental research into the role of Substance P in conditions like migraine, arthritis, depression, and gastrointestinal disorders.

Basic Information

Product Name	Substance P (1-6)
CAS No.	68232-52-0
Molecular Formula	C34H50N10O7S
Molecular Weight	742.89 g/mol
Synonyms	Substance P Fragment 1-6; Arg-Pro-Lys-Pro-Gln-Gln; H-Arg-Pro-Lys-Pro-Gln-Gln-OH; SP (1-6); Neurokinin P (1-6); Substance P (1-6) amide (common misnomer); [Arg1, Pro2, Lys3, Pro4, Gln5, Gln6]-Substance P
EINECS	Contact for details

Quality Control

Our Substance P (1-6) is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). A comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and solvent residues is provided with every shipment to support your regulatory and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Composition	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.