Description

Pyr-His-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Nhet is a synthetic decapeptide amide, a structural analog of Gonadotropin-Releasing Hormone (GnRH). This compound matters as a key research-grade biochemical tool for studying neuroendocrine signaling, receptor binding, and peptide hormone metabolism. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on endocrinology, reproductive biology, and peptide-based therapeutic development. The product is supplied as a high-purity solid under the CAS registry number 67910-55-8.

Application

• Biochemical Research: Used as a reference standard and active agent in studies of the hypothalamic-pituitary-gonadal axis.
• Receptor Binding Assays: Serves as a ligand for investigating the binding affinity and kinetics of GnRH receptors.
• Pharmaceutical Development: Acts as a key intermediate or analog in the research and development of novel peptide therapeutics targeting hormonal disorders.
• Enzymatic Studies: Employed as a substrate to study the activity and inhibition of proteolytic enzymes involved in peptide hormone processing.
• Cell Signaling Research: Utilized to stimulate or modulate cellular responses in vitro models related to reproductive endocrinology.
• Quality Control: Functions as a certified reference material (CRM) for analytical method development and validation in peptide analysis.

Basic Information

Product Name	Pyr-His-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Nhet
CAS No.	67910-55-8
Molecular Formula	C58H81N17O13
Molecular Weight	1200.4 g/mol
Synonyms	GnRH Analog (pGlu-His-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-NH2); Pyroglutamyl-Histidyl-Tryptophyl-Seryl-Tyrosyl-D-Alanyl-Leucyl-Arginyl-Prolyl-Amide; LHRH Analog; Gonadorelin Analog; pGlu-His-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-NH2; Decapeptide Amide; 67910-55-8; Pyr-His-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 (common variant notation)
EINECS	Contact for details

Quality Control

Our Pyr-His-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Nhet is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing purity, related substances, and residual solvents are provided to ensure compliance with research and development standards. We support cGMP-grade production for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This hygroscopic (moisture-sensitive) material should be kept in a cool, dry place and allowed to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption. For optimal stability, store under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area%)	≥ 98.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Amino Acid Analysis	Within ± 10% of theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.