Description

Enkephalinamide-Met, Ala(2)-(Penta-F-Phe)(4)- is a synthetic, fluorinated peptide analog derived from the endogenous opioid peptide enkephalin. This compound is of significant interest in advanced pharmaceutical research due to its enhanced metabolic stability and receptor binding profile conferred by the strategic incorporation of pentafluorophenylalanine residues. It serves as a critical research tool for neuroscientists and medicinal chemists investigating pain modulation, neuropharmacology, and the development of novel opioid receptor ligands. The product is supplied under the CAS registry number 67875-58-5.

Application

• Neuroscience Research: Used as a potent and stable analog to study the role of enkephalinergic systems in pain perception, reward, and addiction.
• Medicinal Chemistry & Drug Discovery: Serves as a key intermediate or reference standard in the design and screening of new non-addictive analgesic compounds targeting delta and mu opioid receptors.
• Biochemical Assay Development: Employed in competitive binding assays (e.g., radioligand binding) to characterize receptor affinity and selectivity profiles of new chemical entities.
• Metabolic Stability Studies: Acts as a model peptide to investigate the effects of fluorination on in vitro and in vivo pharmacokinetic properties, including resistance to enzymatic degradation.
• Academic & Institutional Research: Provides a specialized reagent for universities and research institutes focused on neuropeptide signaling and peptide engineering.

Basic Information

Product Name	Enkephalinamide-Met, Ala(2)-(Penta-F-Phe)(4)-
CAS No.	67875-58-5
Molecular Formula	C46H48F20N6O9
Molecular Weight	1185.90 g/mol
Synonyms	[Met5, Ala2, (pF-Phe)4]-Enkephalinamide; H-Tyr-Gly-Gly-(pentafluoro-Phe)-Leu-NH2 (variant with Ala and Met substitutions); Fluorinated Enkephalin Amide; Opioid Receptor Peptide Ligand; (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]-N-[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-3-[4-(pentafluorophenyl)phenyl]propanamide; Pentafluorophenylalanine4-enkephalin analog
EINECS	Contact for details

Quality Control

Our Enkephalinamide-Met, Ala(2)-(Penta-F-Phe)(4)- is manufactured under controlled conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity verification and mass spectrometry for identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications and test results. We adhere to a quality management system to support the needs of the global research community.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Amino Acid Analysis	Within ± 10% of theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.