Description

Gly-Pro-Arg-Pro CAS NO 67869-62-9 is a synthetic tetrapeptide composed of the amino acids glycine, proline, arginine, and proline. This sequence is of significant interest in biochemical and pharmaceutical research due to its role as a substrate and inhibitor for various proteolytic enzymes. It is primarily utilized by research institutions and manufacturers in the life sciences sector. The compound is essential for studying enzyme kinetics, developing diagnostic assays, and exploring therapeutic applications.

Application

• Enzyme Substrate & Inhibitor Studies: Used as a specific substrate for proteases like thrombin and trypsin in kinetic assays and inhibition profiling.
• Biochemical Research Reagent: Serves as a critical tool in academic and industrial laboratories for investigating protein-protein interactions and peptide metabolism.
• Pharmaceutical R&D: Employed in the discovery and development of novel therapeutic agents targeting coagulation and inflammatory pathways.
• Diagnostic Kit Development: Integrated into in-vitro diagnostic (IVD) kits for the detection and quantification of specific enzyme activities in clinical samples.
• Cell Culture & Signal Transduction Research: Applied in studies of cellular signaling processes where specific peptide sequences modulate biological activity.
• Reference Standard: Used as a high-purity analytical standard for quality control and method validation in peptide synthesis and analysis.

Basic Information

Product Name	Gly-Pro-Arg-Pro
CAS No.	67869-62-9
Molecular Formula	C20H34N8O5
Molecular Weight	466.54 g/mol
Synonyms	GPRP; Gly-Pro-Arg-Pro-OH; H-Gly-Pro-Arg-Pro-OH; Glycyl-prolyl-arginyl-proline; Thrombin Inhibitor Peptide; Benzamidine Tetrapeptide; GPRP Peptide; L-Glycyl-L-prolyl-L-arginyl-L-proline
EINECS	Contact for details

Quality Control

Our Gly-Pro-Arg-Pro is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide Certificates of Analysis (COA) with detailed specifications for traceability and compliance. Our quality commitment ensures the material meets the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For short-term use, store at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Assay (Titration)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.