Description

4-(2-Thienyl)-6-(Trifluoromethyl)Pyrimidin-2-Ol is a high-value pyrimidine derivative characterized by its unique thiophene and trifluoromethyl substituents. This heterocyclic compound serves as a critical advanced pharmaceutical intermediate and a versatile building block in modern organic synthesis. It is primarily required by R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory applications.
• Agrochemical Research: Used as a core scaffold for developing new herbicides, fungicides, and insecticides, leveraging the biological activity of the pyrimidine and thiophene motifs.
• Material Science: Building block for creating organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its conjugated system and electron-withdrawing trifluoromethyl group.
• Chemical Synthesis: Versatile reagent for constructing complex heterocyclic systems in medicinal and process chemistry, enabling structure-activity relationship (SAR) studies.
• Ligand & Catalyst Development: Potential precursor for chelating ligands in catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	4-(2-Thienyl)-6-(Trifluoromethyl)Pyrimidin-2-Ol
CAS No.	67804-95-9
Molecular Formula	C9H5F3N2OS
Molecular Weight	246.21 g/mol
Synonyms	4-(Thiophen-2-yl)-6-(trifluoromethyl)pyrimidin-2-ol; 2-Hydroxy-4-(2-thienyl)-6-(trifluoromethyl)pyrimidine; 6-(Trifluoromethyl)-4-(2-thienyl)pyrimidin-2(1H)-one; 4-(2-Thienyl)-6-(trifluoromethyl)-2(1H)-pyrimidinone; 67804-95-9; 4-(2-Thienyl)-6-trifluoromethylpyrimidin-2-ol
EINECS	Contact for details

Quality Control

Our production of 4-(2-Thienyl)-6-(Trifluoromethyl)Pyrimidin-2-Ol adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure consistent high-grade material suitable for sensitive R&D and scale-up processes. A detailed Certificate of Analysis (COA) is provided with each shipment, and we support custom synthesis to meet specific purity or packaging requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.