Description

2-Ala-5-n-Et-Leu-Enkephalinamide is a synthetic peptide analog of the endogenous opioid peptide enkephalin, specifically modified to enhance metabolic stability and receptor selectivity. This compound is of significant value for advanced research into the opioid receptor system, pain modulation pathways, and the development of novel therapeutic agents. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on neuropharmacology and peptide-based drug discovery.

Application

• Neuroscience Research: Used as a selective tool compound for studying δ-opioid (δ) and mu-opioid (μ) receptor interactions and signaling pathways.
• Analgesic Drug Development: Serves as a key intermediate or reference standard in the design and screening of novel, non-addictive pain management therapies.
• Biochemical Assays: Employed in competitive binding assays, receptor autoradiography, and functional studies (e.g., GTPγS binding) to characterize opioid receptor pharmacology.
• Metabolic Stability Studies: Utilized to investigate the effects of N-terminal alanine and C-terminal amidation on peptide stability against enzymatic degradation.
• Reference Standard: Provides a high-purity benchmark for quality control and analytical method development (HPLC, MS) in peptide synthesis and characterization.

Basic Information

Product Name	2-Ala-5-n-Et-Leu-Enkephalinamide
CAS No.	67787-85-3
Molecular Formula	C33H48N6O8
Molecular Weight	656.77 g/mol
Synonyms	H-Tyr-D-Ala-Gly-Phe-N-ethyl-Leu-NH2; [D-Ala2, N-Ethyl-Leu5]-Enkephalinamide; Tyr-D-Ala-Gly-Phe-NEt-Leu-NH2; 2-Ala-5-N-ethyl-Leu-Enkephalinamide; δ-Selective Enkephalin Analog; Opioid Receptor Peptide Ligand; (5R,8S,11S,14S,17S)-17-Benzyl-14-(4-hydroxyphenyl)-11-((2S)-2-methylbutyl)-5,8-di(propan-2-yl)-2,6,9,12,15-pentaoxo-1-oxa-4,7,10,13,16-pentaazacyclononadecan-14-ium
EINECS	Contact for details

Quality Control

Our 2-Ala-5-n-Et-Leu-Enkephalinamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. We provide comprehensive Certificates of Analysis (COA) detailing all specifications, ensuring compliance with research-grade standards. Our commitment to traceability and batch-to-batch consistency supports reliable and reproducible scientific outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to theoretical molecular weight
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Solubility	Soluble in DMSO, acetic acid; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.